Pharmacology Core Facilities
The Crump Preclinical Imaging Technology Center is a world-class center that facilitates in-vivo preclinical imaging studies for our faculty and collaborators. The Center offers state-of-the-art molecular imaging instrumentation, from digital whole body autoradiography, x-ray micro-computed tomography and micro-positron emission tomography, to bioluminescence and multispectral fluorescence imaging. It also has a fully equipped vivarium that includes a room for surgical and other experimental procedures, and access to a high performance computing infrastructure for data reconstruction, analysis and archiving. The center houses a cyclotron and radiochemistry facilities to produce PET imaging probes and support instrumentation and probe design. Dr. Jason Lee is available to help design experiments, navigate the regulatory environment and teach data analysis techniques.
In-vivo Preclinical Services:
- Contract Work
Dr. Jason Lee
Director of the Preclinical Imaging Technology Center
Department of Pharmacology
The center is composed of two components - ES Cell Core and Transgenic Injection Core. It offers a multitude of services to accommodate individual investigators’ needs in the production of (1) embryonic stem cell targeting, (2) creation of transgenic mice using pronuclear injection and (3) targeted genetic alteration animal models derived from ES cells with targeted mutation. The mission of the center is to provide services with high standards of quality control and in a cost-effective manner. The center serves as a source of expertise to investigators in the design and execution of genetic manipulation on in vivo and in vitro models, on the availability of genetic modified animal models for evaluation, as well as implementation of new methodologies as they arise.
The Quantitative Imaging Computing Center has provided computer support for over 18 years, fully understand the infrastructures of various computer systems, and is able to solve problems promptly. They offer computer system and network support, web portal and database application development, quantitative imaging, processing, reconstruction, archival and retrieval and consultation on computer system solutions.
Dr. Henry Huang
Professor, Department of Pharmacology